REVTx-200 is an intranasal immunomodulator adjunct to be used in combination with an intramuscular vaccination for more complete immunity. Vaccines work by eliciting the production of antibodies via the adaptive immune response. Most vaccines are given intramuscularly and result in a strong systemic immune response (IgG antibodies), but weak mucosal (e.g. the nasal passages) immune response (IgA antibodies).

Since most respiratory viruses enter through the nose, the effectiveness of vaccines may be improved if they produce both systemic and mucosal immunity. It is believed that REVTx-200 will stimulate the production of local intranasal (mucosal) cytokines that will result in the trafficking of activated systemic immune cells (e.g. T and B cells) into the mucosal space resulting in more complete immunity.

REVTx-200 is based on the same technology used in REVTx-99. In a Phase 1 study REVTx-99 stimulated the production of numerous protective cytokines and chemokines including cytokines and chemokines that actively recruit the adaptive immune response which suggests the mechanism described above would work.

Revelation plans to evaluate REVTx-200 in nonclinical models in the first half of 2022 to demonstrate proof of concept.